Many nutritional supplements are available on store shelves with little to no indication as to their safety when taken with one or more other ones. Two supplements that fall into this category are 5-hydroxytryptophan and gamma-aminobutyric acid, more commonly known as 5-HTP and GABA. Combining these supplements in small doses may be safe, but sufficient research does not exist regarding their effects in combination on the human body.
Uses
Some studies show that long-term use of very high dosages of milk thistle will eventually suppress liver function. So remember, milk thistle should be used only as a medicinal herb for detoxification as needed, and for the treatment of liver disorders and other health problems as mentioned above.
GABA is a naturally occurring neurotransmitter that helps to modulate the firing of neurons in your central nervous system when present in your brain. Because of this effect, manufacturers often claim that GABA is useful for relaxation and as a sleep aid. The supplement 5-HTP is a precursor to the mood-calming chemical serotonin, and some studies have shown it to be effective in treating depression and insomnia. Though 5-HTP has been demonstrated to be mildly effective, GABA has not for most uses, because it has difficulty crossing the blood-brain barrier. Therefore, GABA is unlikely to provide any additional relaxation effects when used in combination with 5-HTP.
Contraindications
According to the NYU Langone Medical Center, there are no known contraindications for GABA, meaning that it is potentially safe to take it with 5-HTP. However, the medical institution adds that there are no significant studies regarding GABA's interactions with other supplements, so there is no guarantee that you can safely use them in combination.
Denosyl has been shown to increase the level of glutathione, an antioxidant that can fight deadly toxins in your pet's body. For optimal absorption, it should be taken on an empty stomach. Cautions: Denosyl tablets must be given to your pet whole. Store this product in a cool and dry place. Keep tablets in the original blister pack until they are used. Sep 21, 2009 Denosyl is an excellent product to consider and has a sufficient amount of SAMe to make a clinical difference in many pets. Vetri-DMG helps with chemical reactions in many cells, including the transfer of oxygen by the blood and into the brain. Yes, your veterinarian may recommend combining Denosyl with other products and/or dietary modifications. One such product is called Marin ® Plus, which can be administered with Denosyl for additional liver health support. There are no known adverse interactions of Denosyl with drugs or other supplements.
Natural Occurrence
Little is known about the interaction of 5-HTP and GABA in supplement form, but it is likely that you have consumed both in limited doses from your diet. In a GABA safety proposal received by the U.S. Food and Drug Administration in 2008, the research team of Pharma Foods International states that GABA naturally occurs in small doses in fermented foods, melons, tomatoes and potatoes. 5-HTP does not occur naturally in food, but its precursor amino acid tryptophan occurs in turkey, milk and potatoes.
Safe Dosage
Best-selling supplement author Ray Sahelian, MD claims that you are unlikely to have a negative drug interaction when you combine 5-HTP and GABA in small amounts. He adds that you should always speak to a physician before combining the two supplements, because each person has a unique physiology that may present complications. Recommended dosages for GABA can range widely from 10 mg to 1000 mg depending on its prescribed use, and 5-HTP carries a recommended dosage of up to 150 mg per day.
This page contains information on Denosyl for
Can Dmg Be Used In Combination With Denosyl And Anxietyveterinary use.The information provided typically includes the following:
DenosylThis treatment applies to the following species:Company: Nutramax Labs.
(S-Adenosylmethionine)
Sold through veterinarians
Denosyl, a supplement, is the pure and stabilized salt of S-Adenosylmethionine for veterinary use only. It has been researched in published U.S. trials in dogs and cats. Denosyl is available in three strengths: as an enteric-coated 90 mg, 225 mg, and 425 mg tablet of active S-Adenosylmethionine. Because S-Adenosylmethionine is extremely sensitive to moisture, tablets are individually sealed in specialized moisture-resistant blister packs.
Background
S-Adenosylmethionine is an endogenous molecule synthesized by cells throughout the body and is formed from the amino acid methionine and ATP. It is an essential part of three major biochemical pathways: transmethylation, transsulfuration and aminopropylation. As part of these pathways, S-Adenosylmethionine is essential to all cells and is particularly important in hepatocytes because of their central role in metabolism. A deficiency of S-Adenosylmethionine, therefore, may initiate or contribute to abnormalities of cellular structure and function in the liver as well as many other body tissues, including the brain.1-4
Conversely, exogenous administration of S-Adenosylmethionine has been shown to result in improvements in hepatocellular function in both in vivo and in vitro studies, without cytotoxicity or significant side effects.1-3,5-10 Precursors of S-Adenosylmethionine do not have similar effects. Administration of methionine to animals with decreased liver function may not increase hepatic S-Adenosylmethionine levels and may be toxic.2 The best way to increase S-Adenosylmethionine levels in the body is by direct supplementation with S-Adenosylmethionine.
PurposeCan Dmg Be Used In Combination With Denosyl Good
Denosyl has been shown to increase hepatic glutathione levels in cats and dogs.1,3 Glutathione is a potent antioxidant that protects hepatic cells from toxins and death. A study found that low liver glutathione concentrations are common in dogs and cats with decreased hepatobiliary function.11 Denosyl is recommended to improve hepatic glutathione levels in patients to help maintain and protect liver function. Denosyl may also be used in other areas of tissue oxidant injury and RBC fragility caused by certain toxins or drugs which are related to reduced glutathione concentrations.2 Denosyl, however, goes beyond increasing glutathione levels and has been shown to protect liver cells from cell death5,9 and may be useful in cell regeneration.2 A study has also shown that Denosyl may improve bile flow in cats.8
In addition to supporting liver health, Denosyl may also support brain health as S-Adenosylmethionine has been shown to function as a neuroprotective agent.4,12,13
Pharmacokinetics
In a pharmacokinetic study with fasted dogs given Denosyl, peak plasma levels were recorded in most dogs within 4 hours of administration.1 A pharmacokinetic study in fasted cats showed peak plasma levels at 2-4 hours post Denosyl administration.14
Safety
Denosyl demonstrates an exceptionally wide margin of safety. Oral acute toxicity studies with S-Adenosylmethionine in rats indicated an LD50 greater than 4,650 mg/kg.2 Clinically healthy dogs administered 20 mg/kg/day of Denosyl for 6 weeks and clinically healthy cats administered Denosyl at 2 times the recommended daily amount for 113 days remained healthy with no adverse effects from administration of Denosyl.1,3
Administration As A Supplement
Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole tablet. The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.
For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty administering tablets to their pets, Denosyl® tablet(s) may be disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a “dry swallow” do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.15,16 Denosyl 90 mg tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.
Feline And Canine Denosyl Daily* Administration Guide
For Cats
For Small Dogs
Can Dmg Be Used In Combination With Denosyl Prices
For Medium Dogs
For Large Dogs
*The number of tablets can be gradually reduced or increased at any time depending on the pet’s needs.
Many pets are maintained long-term on every-other-day or every-third-day administration.
Storage
Store in a cool dry place. Keep tablets in original blister pack until used.
Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.
Also available in chewable tablets for dogs.
Contact your veterinarian or go to nutramaxlabs.com to learn more.
REFERENCES
1. Center SA, Warner KL, McCabe J, et al. Am J Vet Res 2005;66(2):330-341.
2. Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.
3. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
4. Tchantchou F, Graves M, Ortiz D, et al. J Nutr Health Aging 2006;10(6):541-544.
5. Webster CRL, Boria P, Usechak P, Anwer MS. Vet Therapeutics 2002;3(4):474-484.
6. Wallace KP, Center SA, Hickford FH, et al. J Am Anim Hosp Assoc 2002;38:246-254.
7. Webb CB, Twedt DC, Fettman MJ, Mason G. J Fel Med & Surg 2003;5:69-75.
8. Center SA, Warner KL. In Proceedings. 22nd Annual ACVIM Forum 2004;867-868.
9. McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003; abstract #134.
10. Watson PJ, Scott L, Smith N, Marlin DJ. In Proceedings. ECVIM-CA/ESVIM 2002;178.
11. Center SA, Warner KL, Erb HN. Am J Vet Res 2002;63(8):1187-1197.
12. Tchantchou F, Graves M, Falcone D, Shea TB. J Alzheimers Dis 2008;14:323-328.
13. Shea TB, Chan A. J Alzheimers Dis 2008;13:67-70.
14. Center SA, Warner KL. World Veterinary Congress, 2002.
15. Westfall DS, Twedt DC, Steyn PF, et al. J Vet Intern Med 2001;15(5):467-470.
16. Graham JP, Lipman AH, Newell SM, Roberts GD. Am J Vet Res 2000;61(6):655-657.
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